Effects of ferrous sulfate supplementation on bone marrow hemopoiesis in rats.
- Author:
Qing-jun YANG
1
;
Jian-qiang LAI
;
Jing MENG
;
Bao-Li XING
;
Hui LIU
;
Shi-an YIN
;
Xian-feng ZHAO
;
Qing-mei XU
Author Information
- Publication Type:Journal Article
- MeSH: Anemia, Iron-Deficiency; drug therapy; Animals; Bone Marrow; drug effects; Disease Models, Animal; Female; Ferrous Compounds; pharmacology; Hematopoiesis; drug effects; Rats; Rats, Wistar
- From: Chinese Journal of Preventive Medicine 2006;40(5):332-335
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the influences of different dosage ferrous sulfate supplements on bone marrow hemopoiesis in rats.
METHODSFemale weaning Wistar rats were fed with an iron deficient diet (< 10 mg/kg diet) until the level of hemoglobin of rats was lower than 100 g/L. Rats (n = 50) were randomly divided into five groups according to the levels of hemoglobin and body weight, iron deficiency control (ID), daily low iron diet supplement (LDs), daily high iron diet supplement (HDs), weekly low iron supplement (LWs), and weekly high iron supplement (HWs).
RESULTSAfter 12 weeks, bone marrow stainable iron was seldom in ID group, and ample in supplement groups. The proportions of iron staining of bone marrow smear in supplement groups were more than 30%. Bone marrow cells in all rats were hyperplastic or active hyperplastic.
CONCLUSIONSDaily high iron supplement or once weekly high iron supplement were safe to bone marrow hemopoiesis in rats.
