Analysis of genetic characteristics of wild-type measles viruses in Jilin Province 2005.
- Author:
Jiang BIAN
1
;
Fan LI
;
Shi-hong YI
Author Information
- Publication Type:Journal Article
- MeSH: China; Genes, Reporter; Genes, Viral; Genotype; Humans; Measles; epidemiology; virology; Measles virus; genetics; Molecular Sequence Data; Viral Structural Proteins; genetics
- From: Chinese Journal of Preventive Medicine 2006;40(5):348-350
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the know gene types of main wild type measles virus strains and take measures to control measles in Jilin Province.
METHODSGenetic characterization of 9 measles viruses isolated from 72 throat swabs or urine specimens of measles patients using CDW(150) cells line was studied in Jilin Province in 2005.
RESULTSSequence analysis of 450 nucleotides of COOH-terminal of nucleoprotein (N) genes of 9 isolates indicated that all were members of H(1) genotype, in which there are 7 strains of H1a and 2 strains of H1b, the H1a subgroup differed from H1b by 2.0% approximately 3.5% at the nucleotide level in the COOH-terminal of the N gene.
CONCLUSIONSThe H(1) genotype of wild-type measles viruses should be the main epidemic strain and main pathogen that caused measles outbreaks and sporadic cases in Jilin Province.
