Effects on serum glucose and lipids in chronic exposure to lanthanum chloride in rat.
- Author:
Tian-Cheng WANG
1
;
Xiao HE
;
Zhi-Yong ZHANG
;
Guang JIA
;
Xiang WANG
;
Hui-Qi SHEN
;
Yu-Liang ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Glucose; Cholesterol; blood; Cholesterol, HDL; blood; Cholesterol, LDL; blood; Environmental Exposure; Glycated Hemoglobin A; Lanthanum; toxicity; Lipids; blood; Male; Rats; Rats, Wistar; Triglycerides; blood
- From: Chinese Journal of Preventive Medicine 2006;40(6):419-421
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effects of serum glucose and lipids by on chronically lanthanum exposure in rat.
METHODSThe Wistar rats were treated with oral exposure dose 0.1, 2 and 40 mg/kg of lanthanum chloride (LaCl(3)) respectively, after 90 days the rats were sacrificed and the blood was collected for measuring the glycosylated hemoglobin A (HbA1c), the serum was used for measuring glucose, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) levels.
RESULTSThere were no any differences among the control and 3 dose LaCl(3) exposed rats on the blood HbA1c and serum Glu, TG and LDL-C levels (P > 0.05). The serum TC in 0.1 and 2 mg/kg LaCl(3) dose group rats were (1.38 +/- 0.14) mmol/L and (1.37 +/- 0.26) mmol/L respectively. It was lower than that of the controls (1.57 +/- 0.14) mmol/L significantly (P < 0.05), the serum HDL-C in 0.1 mg/kg dose group rats was (0.79 +/- 0.12) mmol/L and obviously lower than that of control group rats (0.93 +/- 0.10) mmol/L (P < 0.05).
CONCLUSION0.1 - 40 mg/kg LaCl(3) chronically exposed have not greater effect on serum glucose, TG and LDL-C levels in rats, but the lower dose LaCl(3) chronic exposure might cause serum TC and HLD-C level decreasing.
