Aberrant methylation of APC and Bikunin CpG islands in sporadic breast carcinomas.
- Author:
Yang-Lin CHEN
1
;
Yun-Tao XIE
;
Xian-Zi WEN
;
Da-Jun DENG
Author Information
- Publication Type:Journal Article
- MeSH: Breast Neoplasms; genetics; pathology; CpG Islands; DNA Methylation; DNA, Neoplasm; genetics; Female; Follow-Up Studies; Humans
- From: Chinese Journal of Preventive Medicine 2007;41 Suppl():17-19
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate relationship between methylation status of the APC and Bikunin CpG islands and clinicopathological characteristics of breast carcinomas.
METHODSThe methylation status of APC and Bikunin CpG islands in 152 sporadic breast carcinoma samples were analyzed by methylation specific PCR.
RESULTS40.8% of breast carcinomas examined showed methylated signals for the APC. The methylation frequency of APC was significantly correlated to the tumor size (chi(2) = 4.041; P = 0.044), but not to patients' age, pathologic type of tumor, clinical stage, histological grade, lymph node metastasis and the status of estrogen or progestogen receptor. In addition, 24.6% of carcinoma samples examined revealed strong methylated signals for Bikunin. No significant correlation was found between the aberrant methylation of Bikunin and the clinicopathological characteristics of sporadic breast carcinomas.
CONCLUSIONThe aberrant methylations of APC and Bikunin are frequent events during breast carcinogenesis. APC methylation might play a role in the progression of breast cancer.
