Meta-analysis on the relationship between IL8-251 gene polymorphism and gastric cancer.
- Author:
Yan LU
1
;
Zi-Dun WANG
;
Jing SHEN
;
Yao-Chu XU
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-8; genetics; Polymorphism, Genetic; Stomach Neoplasms; genetics
- From: Chinese Journal of Preventive Medicine 2007;41 Suppl():39-42
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the relationship between IL8-251 gene polymorphisms and gastric cancer.
METHODSLiteratures were reviewed and selected based on the criteria for inclusion. The Meta-analysis software, REVMAN 4.2, was applied to check the heterogeneity across the studies and calculating the pooled OR.
RESULTSTotal of 2114 cases and 2505 controls from 8 studies for IL8-251 were included. The chi(2) value was 21.48 (P = 0.003), and the pooled OR of (AA + AT) vs. TT was 1.12 (95% CI 0.90 - 1.40). Large heterogeneity was found among the studies. After the sensitivity analysis, the pooled OR of (AA + AT) vs. TT 1.21 (95% CI 1.06 - 1.39).
CONCLUSIONIL8-251-A allele might be associated with higher risk of developing gastric cancer.
