Effect of selenium-enriched garlic on chronic gastritis of the glandular stomach of Mongolian gerbils induced by H. pylori.
- Author:
Lian-Kun GU
1
;
Ping ZHOU
;
Jing ZHOU
;
Ru-Ming WANG
;
Wen-Jie YANG
;
Da-Jun DENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chronic Disease; Disease Models, Animal; Garlic; Gastritis; drug therapy; microbiology; Gerbillinae; Helicobacter Infections; drug therapy; Helicobacter pylori; Male; Phytotherapy; Selenium; therapeutic use
- From: Chinese Journal of Preventive Medicine 2007;41 Suppl():104-107
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the therapeutic effect of selenium-enriched garlic (SeG) on chronic gastritis.
METHODSChronic gastritis was induced of the glandular stomach of male Mongolian Gerbils via gastric instillation of H. pylori TN2 strain once every 4 days for 5 consecutive times followed by random classification into six groups. Fresh SeG suspension was administrated daily at dosages of 4.70, 1.5, 0.47, 0.15 g.kg(-1).d(-1) for four weeks. The gerbils in the positive control group were treated with omeprazole, clarithromycin, and amoxicillin for one week. The gerbils were killed for pathological examination four weeks after SeG-treatment.
RESULTSChronic gastritis (CAG), low-grade dysplasia or gastric intraepithelial neoplasia (DYS/GIN) were observed among 77% and 38.5% of the 13 H. pylori-treated animals in the negative control group, respectively; whereas 40% and 26.7% in the positive control group (n = 15), respectively. The incidences of CAG and DYS/GIN in the SeG groups (n = 21 - 27) were reduced dose-dependently, 16.7% - 38.7% and 11.1% - 14.3% for CAG and DYS/GIN, respectively.
CONCLUSIONSeG administration inhibits the development and progression of CAG induced by H. pylori remarkably.
