Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles (Microtus ochrogaster).

Andrew H Jheon; Michaela Prochazkova; Michael Sherman; Devanand S Manoli; Nirao M Shah; Lawrence Carbone; Ophir Klein

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Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles (Microtus ochrogaster).

Author: Andrew H JHEON ¹ ; Michaela PROCHAZKOVA ² ; Michael SHERMAN ³ ; Devanand S MANOLI ⁴ ; Nirao M SHAH ⁵ ; Lawrence CARBONE ³ ; Ophir KLEIN ¹
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1. Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California, San Francisco (UCSF), San Francisco, USA.
2. 1] Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California, San Francisco (UCSF), San Francisco, USA [2] Department of Anthropology and Human Genetics, Faculty of Science, Charles University in Prague, Prague, Czech Republic.
3. Laboratory Animal Resource Center, UCSF, San Francisco, USA.
4. 1] Department of Psychiatry, UCSF, San Francisco, USA [2] Department of Anatomy, UCSF, San Francisco, USA.
5. Department of Anatomy, UCSF, San Francisco, USA.
Publication Type:Journal Article
MeSH: Animals; Arvicolinae; anatomy & histology; genetics; Female; Humans; Male; Molar; diagnostic imaging; growth & development; Pedigree; X-Ray Microtomography
From: International Journal of Oral Science 2015;7(1):23-26
CountryChina
Language:English
Abstract: Continuously growing incisors are common to all rodents, which include the Microtus genus of voles. However, unlike many rodents, voles also possess continuously growing molars. Here, we report spontaneous molar defects in a population of Prairie voles (Microtus ochrogaster). We identified bilateral protuberances on the ventral surface of the mandible in several voles in our colony. In some cases, the protuberances broke through the cortical bone. The mandibular molars became exposed and infected, and the maxillary molars entered the cranial vault. Visualisation upon soft tissue removal and microcomputed tomography (microCT) analyses confirmed that the protuberances were caused by the overgrowth of the apical ends of the molar teeth. We speculate that the unrestricted growth of the molars was due to the misregulation of the molar dental stem cell niche. Further study of this molar phenotype may yield additional insight into stem cell regulation and the evolution and development of continuously growing teeth.