Dental anomalies in first-degree relatives of transposed canine probands.

Adriana Bartolo; Neville Calleja; Fraser Mcdonald; Simon Camilleri

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Dental anomalies in first-degree relatives of transposed canine probands.

Author: Adriana BARTOLO ¹ ; Neville CALLEJA ² ; Fraser MCDONALD ³ ; Simon CAMILLERI ³
Author Information

1. Broadstreet Dental Centre, Hamrun, Malta.
2. Department of Public Health, Medical School, University of Malta, Tal-Qroqq, Malta.
3. Dental Institute, Department of Orthodontics, Kings College London, London, UK.
Publication Type:Journal Article
MeSH: Cuspid; abnormalities; diagnostic imaging; Family; Humans; Radiography, Panoramic; Tooth Abnormalities; etiology; genetics
From: International Journal of Oral Science 2015;7(3):169-173
CountryChina
Language:English
Abstract: The aim of this study was to investigate and compare the inheritance pattern and prevalence of inheritable dental anomalies in a sample of patients with maxillary canine-first premolar transposition and their first-degree relatives with a sample of palatally displaced canine families. Thirty-five consecutive maxillary canine-first premolar transposition probands and 111 first-degree relatives were matched to 35 consecutive palatally displaced canine probands and 115 first-degree relatives. These were assessed for palatally displaced canines and incisor-premolar hypodontia. Parental age at birth of the proband was also noted. The results revealed that (i) there is no difference in the overall prevalence of palatally displaced canine or incisor-premolar hypodontia between the groups of relatives; (ii) first-degree relatives of bilateral palatally displaced canine probands have a higher prevalence of palatally displaced canine and incisor-premolar hypodontia than those with unilateral palatally displaced canine; and (iii) maternal age at birth of the maxillary canine-first premolar transposition probands was significantly higher than that of the palatally displaced canine probands. The results suggest that maxillary canine-first premolar transposition and palatally displaced canine are unlikely to be different genetic entities and also indicate environmental or epigenetic influences on dental development.