The role of microRNAs in bone remodeling.

Author: Dian JING ¹ ; Jin HAO ¹ ; Yu SHEN ¹ ; Ge TANG ¹ ; Mei-Le LI ¹ ; Shi-Hu HUANG ¹ ; Zhi-He ZHAO ¹
Author Information

1. State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Publication Type:Journal Article
MeSH: Animals; Bone Remodeling; physiology; Cell Lineage; Humans; MicroRNAs; physiology; Osteoblasts; cytology; Transcription, Genetic
From: International Journal of Oral Science 2015;7(3):131-143
CountryChina
Language:English
Abstract: Bone remodeling is balanced by bone formation and bone resorption as well as by alterations in the quantities and functions of seed cells, leading to either the maintenance or deterioration of bone status. The existing evidence indicates that microRNAs (miRNAs), known as a family of short non-coding RNAs, are the key post-transcriptional repressors of gene expression, and growing numbers of novel miRNAs have been verified to play vital roles in the regulation of osteogenesis, osteoclastogenesis, and adipogenesis, revealing how they interact with signaling molecules to control these processes. This review summarizes the current knowledge of the roles of miRNAs in regulating bone remodeling as well as novel applications for miRNAs in biomaterials for therapeutic purposes.