Histone methyltransferases and demethylases: regulators in balancing osteogenic and adipogenic differentiation of mesenchymal stem cells.

Peng Deng; Qian-ming Chen; Christine Hong; Cun-yu Wang

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Histone methyltransferases and demethylases: regulators in balancing osteogenic and adipogenic differentiation of mesenchymal stem cells.

Author: Peng DENG ¹ ; Qian-Ming CHEN ² ; Christine HONG ³ ; Cun-Yu WANG ¹
Author Information

1. Division of Oral Biology and Medicine, School of Dentistry, University of California at Los Angeles, Los Angeles, USA.
2. State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu, China.
3. Section of Orthodontics, School of Dentistry, University of California at Los Angeles, Los Angeles, USA.
Publication Type:Journal Article
MeSH: Adipogenesis; genetics; physiology; Cell Differentiation; genetics; physiology; Cell Lineage; genetics; Epigenesis, Genetic; genetics; F-Box Proteins; genetics; physiology; Histone Demethylases; genetics; physiology; Histone-Lysine N-Methyltransferase; genetics; physiology; Humans; Jumonji Domain-Containing Histone Demethylases; genetics; physiology; Mesenchymal Stromal Cells; enzymology; physiology; Methyltransferases; genetics; physiology; Osteogenesis; genetics; physiology
From: International Journal of Oral Science 2015;7(4):197-204
CountryChina
Language:English
Abstract: Mesenchymal stem cells (MSCs) are characterized by their self-renewing capacity and differentiation potential into multiple tissues. Thus, management of the differentiation capacities of MSCs is important for MSC-based regenerative medicine, such as craniofacial bone regeneration, and in new treatments for metabolic bone diseases, such as osteoporosis. In recent years, histone modification has been a growing topic in the field of MSC lineage specification, in which the Su(var)3-9, enhancer-of-zeste, trithorax (SET) domain-containing family and the Jumonji C (JmjC) domain-containing family represent the major histone lysine methyltransferases (KMTs) and histone lysine demethylases (KDMs), respectively. In this review, we summarize the current understanding of the epigenetic mechanisms by which SET domain-containing KMTs and JmjC domain-containing KDMs balance the osteogenic and adipogenic differentiation of MSCs.