Association Analysis of Proteasome Subunits and Transporter Associated with Antigen Processing on Chinese Patients with Parkinson's Disease.
- Author:
Ming-Shu MO
;
Wei HUANG
;
Cong-Cong SUN
;
Li-Min ZHANG
;
Luan CEN
;
You-Sheng XIAO
;
Guo-Fei LI
;
Xin-Ling YANG
;
Shao-Gang QU
;
Ping-Yi XU
1
;
Author Information
- Publication Type:Journal Article
- MeSH: ATP-Binding Cassette Sub-Family B Member 2; genetics; ATP-Binding Cassette, Sub-Family B, Member 3; genetics; Adult; Aged; Antigen Presentation; Case-Control Studies; Cysteine Endopeptidases; genetics; Female; Humans; Male; Middle Aged; Parkinson Disease; genetics; immunology; Polymorphism, Single Nucleotide; Proteasome Endopeptidase Complex; genetics
- From: Chinese Medical Journal 2016;129(9):1053-1058
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDProteasome subunits (PSMB) and transporter associated with antigen processing (TAP) loci are located in the human leukocyte antigen (HLA) Class II region play important roles in immune response and protein degradation in neurodegenerative diseases. This study aimed to explore the association between single nucleotide polymorphisms (SNPs) of PSMB and TAP and Parkinson's disease (PD).
METHODSA case-control study was conducted by genotyping SNPs in PSMB8, PSMB9, TAP1, and TAP2 genes in the Chinese population. Subjects included 542 sporadic patients with PD and 674 healthy controls. Nine identified SNPs in PSMB8, PSMB9, TAP1, and TAP2 were genotyped through SNaPshot testing.
RESULTSThe stratified analysis of rs17587 was specially performed on gender. Data revealed that female patients carry a higher frequency of rs17587-G/G versus (A/A + G/A) compared with controls. But there was no significant difference with respect to the genotypic frequencies of the SNPs in PSMB8, TAP1, and TAP2 loci in PD patients.
CONCLUSIONChinese females carrying the rs17587-G/G genotype in PSMB9 may increase a higher risk for PD, but no linkage was found between other SNPs in HLA Class II region and PD.
