Association between Carotid Intima-media Thickness and Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism in Chinese Han with Essential Hypertension.

Xiao-Xiang MA; Shu-Zhan ZHENG; Yan SHU; Yong WANG; Xiao-Ping CHEN

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Association between Carotid Intima-media Thickness and Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism in Chinese Han with Essential Hypertension.

Author: Xiao-Xiang MA ^{1
,

2} ; Shu-Zhan ZHENG ³ ; Yan SHU ⁴ ; Yong WANG ⁵ ; Xiao-Ping CHEN ⁶
Author Information

1. Center of Health Physical Examination and Health Management, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072
2. Department of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
3. Department of Cardiology, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, China.
4. Department of Cardiology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, China.
5. Department of Cardiovascular, Xinqiao Hospital, Third Military Medical University, Chongqing, Sichuan 400037, China.
6. Department of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Publication Type:Journal Article
MeSH: Adult; Aged; Aldehyde Dehydrogenase, Mitochondrial; genetics; Asian Continental Ancestry Group; Carotid Intima-Media Thickness; China; Essential Hypertension; Female; Genetic Predisposition to Disease; Genotype; Humans; Hypertension; genetics; Logistic Models; Male; Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; genetics; Risk Factors
From: Chinese Medical Journal 2016;129(12):1413-1418
CountryChina
Language:English
Abstract:
BACKGROUNDAldehyde dehydrogenase 2 (ALDH2) is involved in the pathophysiological processes of cardiovascular diseases. Recent studies showed that mutant ALDH2 could increase oxidative stress and is a susceptible factor for hypertension. In addition, wild-type ALDH2 could improve the endothelial functions, therefore reducing the risk of developing atherosclerosis. The aim of the present study was to explore the frequency of the Glu504Lys polymorphism of the ALDH2 gene and its relation to carotid intima-media thickness (CIMT) in a group of patients with essential hypertension (EH) and to investigate the association between the Glu504Lys polymorphism and CIMT in Chinese Han patients with EH.
METHODSIn this study, 410 Chinese Han patients with EH who received physical examinations at the People's Hospital of Sichuan Province (China) were selected. DNA microarray chip was used for the genotyping of the Glu504Lys polymorphism of the ALDH2 gene. The differences in CIMT among patients with different Glu504Lys ALDH2 genotypes were analyzed.
RESULTSThe mean CIMT of the patients carrying AA/AG and GG genotypes was 1.02 ± 0.31 mm and 0.78 ± 0.28 mm, respectively. One-way ANOVA showed that the CIMT of the patients carrying the AA/AG genotype was significantly higher than in the ones carrying the GG genotype (P < 0.001). Multivariate logistic regression showed that the Glu504Lys AA/AG genotype of the ALDH2 gene was one of the major factors influencing the CIMT in patients with EH (odds ratio = 3.731, 95% confidence interval = 1.589-8.124, P = 0.001).
CONCLUSIONSThe Glu504Lys polymorphism of the ALDH2 gene is associated with the CIMT of Chinese Han patients with EH in Sichuan, China.