Correlation of adiponectin, monocyte chemoattractant protein-1, and endothelial function to vascular remodeling in coronary in-stent restenosis.
- Author:
Zhi-bing WANG
1
;
Jun LIU
;
Shao-yuan CHEN
;
You-su SU
;
Pei-yi XIE
;
Hong-cheng FANG
Author Information
- Publication Type:Journal Article
- MeSH: Adiponectin; blood; Adult; Aged; Angioplasty, Balloon, Coronary; Chemokine CCL2; blood; Coronary Disease; blood; physiopathology; therapy; Coronary Restenosis; blood; etiology; Endothelium, Vascular; physiopathology; Female; Humans; Male; Middle Aged; Stents; adverse effects
- From: Journal of Southern Medical University 2010;30(4):912-914
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the correlation between vascular remodeling index (RI) and serum adiponectin, plasma monocyte chemoattractant protein-1 (MCP-1), endothelial function and evaluate the mechanism of coronary in-stent restenosis.
METHODSRI 6 months after percutaneous coronary intervention (PCI), serum adiponectin, plasma MCP-1 and flow-mediated dilation (FMD) before and 3 days,6 months after PCI were measured in 30 patients with and 30 without coronary in-stent restenosis.
RESULTSCompared with patients without restenosis and those with restenosis before PCI, the patients with coronary in-stent restenosis showed significantly increased plasma MCP-1 3 days and 6 months after PCI (P<0.05) and reduced RI 6 months after PCI, serum adiponectin and FMD 3 days and 6 months after PCI (P<0.05). RI was positively correlated to serum adiponectin and FMD and inversely to MCP-1.
CONCLUSIONThe occurrence of coronary in-stent restenosis is the result of the interrelations between multiple factors.
