Protective effect of polydatin on a PC12 cell model of oxygen-glucose deprivation.
- Author:
Bing XU
1
;
Huan-bing LIN
;
Heng ZHOU
;
Jiang-ping XU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain Ischemia; metabolism; prevention & control; Cell Survival; Glucose; metabolism; pharmacology; Glucosides; pharmacology; L-Lactate Dehydrogenase; analysis; Malondialdehyde; analysis; Nitric Oxide; analysis; Oxygen; metabolism; pharmacology; PC12 Cells; Protective Agents; pharmacology; Rats; Stilbenes; pharmacology; Superoxide Dismutase; metabolism
- From: Journal of Southern Medical University 2010;30(5):1041-1043
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the protective effect of polydatin on a PC12 cell model of oxygen and glucose deprivation (OGD).
METHODSA pheochromocytoma cell injury model was induced by OGD to simulate the cerebral ischemic changes. The protective effects of polydatin were investigated in this model.
RESULTSPolydatin treatment significantly enhanced the cell viability and reduced the levels of lactate dehydrogenase, nitric oxide and the malondialdehyde of the pheochromocytoma cells as compared with the OGD group. Polydatin also increased the activity of superoxide dismutase in the cells.
CONCLUSIONPolydatin offers protective effect against OGD-induced injury in pheochromocytoma cells.
