Effects of etomidate infusion on serum cortisol in patients undergoing radical resection of lung cancer.
- Author:
Yong-qiu XIE
1
;
He-na JIAO
;
Qu-lian GUO
;
Chan CHENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Anesthesia, General; Etomidate; administration & dosage; Female; Humans; Hydrocortisone; blood; Lung Neoplasms; blood; surgery; Male; Middle Aged; Pneumonectomy; methods; Postoperative Period; Young Adult
- From: Journal of Southern Medical University 2010;30(5):1047-1049
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effect of etodimate infusion on serum cortisol in patients undergoing radical resection of lung cancer operations during the perioperative period.
METHODSForty ASA I-II patients undergoing radical resection of lung cancer were randomly divided into etomidate group (Group E) and propofol group (Group P) (n=20). The serum cortisol was measured at 8:00 am (T(0)) before anesthesia, 4:00 pm (T(1)) on the day of operation and 24 h after the operation (T(2)) by radioimmunoassay.
RESULTSCompared with that at T0, the serum level of cortisol significantly increased at 24 h after the operation in both groups (P<0.01); serum cortisol decreased lightly at T1, which was not statistically significant (P>0.05), and remained higher than the normal level. At each of the time points, serum cortisol levels were comparable between the two groups (P>0.05).
CONCLUSIONEtomidate infusion can not inhibit the synthesis of cortisol in patients undergoing radical resection of lung cancer.
