Effect of metoprolol on the expression of GRK2 in lymphocyte of advanced elderly patients with chronic heart failure.
- Author:
Wen-qian GAO
1
;
Chun-guang HAN
;
Yue-xiang ZHAO
;
Qiong WANG
;
Ping ZHU
;
Ting-shu YANG
;
Yong-xue LIU
Author Information
- Publication Type:Journal Article
- MeSH: Aged, 80 and over; Chronic Disease; G-Protein-Coupled Receptor Kinase 2; blood; genetics; metabolism; Heart Failure; metabolism; Humans; Lymphocytes; metabolism; Metoprolol; pharmacology
- From: Journal of Southern Medical University 2010;30(5):1132-1133
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of metoprolol on the expression of G protein-coupled receptor kinases 2 (GRK2) in lymphocyte of advanced elderly patients with chronic heart failure.
METHODS32 elderly patients with chronic heart failure were divided into control group and metoprolol group, 16 each. Conventional therapy was used in the control group, conventional therapy plua metoprolol was used in metoprolol group. The treatment courses were 8 weeks in both groups.
RESULTSLeft ventricular end-diastolic diameter and left ventricular ejection fraction were not different between the two groups. Lymphocyte GRK2 mRNA level in metoprolol group was lower than that in control group.
CONCLUSIONMetoprolol can inhibit the expression of GRK2 in lymphocyte of advanced elderly patients with chronic heart failure.
