Expression of osteopontin and survivin in prostate cancer and the clinical significance.
- Author:
Hong-bo YU
1
;
Xiao-bing HAN
;
Yi-qian LIANG
;
Jian-gang LIU
;
Hao WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Humans; Inhibitor of Apoptosis Proteins; genetics; metabolism; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Osteopontin; biosynthesis; genetics; Prostatic Neoplasms; metabolism; pathology; RNA, Messenger; genetics; metabolism
- From: Journal of Southern Medical University 2010;30(5):1141-1143
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the expression of osteopontin (OPN) and survivin in prostate cancer tissue, and study their correlation and roles in tumor invasion and metastasis.
METHODSThe expressions of OPN and survivin in prostate cancer tissue, prostate hyperplasia tissue and normal prostate tissue were determined by RT-PCR and immunohistochemistry.
RESULTSThe positive expression rates of OPN mRNA and protein in prostate cancer tissue [76.1% (35/46) and 69.6% (32/46)] were significantly correlated to survivin expression [67.4% (31/46) and 67.4% (31/46)] (P<0.05). The expressions of OPN and survivin were related to the tumor grade and clinical stages (P<0.05). OPN and survivin were not found in prostate hyperplasia and normal prostate tissues.
CONCLUSIONOPN and survivin may play important roles in the progression of prostate cancer and can be potential markers for invasion and metastasis of prostate cancer. OPN and survivin might play synergetic roles in prostate carcinogenesis.
