Role of matrix metalloproteinase and tissue inhibitor of metalloproteinase in atrial structural remodeling in patients with atrial fibrillation.
- Author:
Wei WANG
1
;
Ping-sheng WU
;
Xi-li YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Atrial Fibrillation; enzymology; pathology; physiopathology; Female; Humans; Male; Matrix Metalloproteinases; genetics; metabolism; Middle Aged; Tissue Inhibitor of Metalloproteinases; genetics; metabolism
- From: Journal of Southern Medical University 2010;30(5):1160-1162
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the relationship between atrial structural remodeling and the expressions of matrix metalloproteinase (MMPs) and their tissue inhibitors (TIMPs) in atrial fibrillation (AF).
METHODSBiopsy samples of the right atrial appendages were collected from 20 patients with sinus rhythm and 30 with AF undergoing heart valve replacement surgery for rheumatic heart diseases. All the patients received echocardiographic examination preoperatively. MMP-1, -3, -7, -9 and TIMP-1, -2, -3, -4 protein expressions were detected by immunohistochemistry and RT-PCR.
RESULTSCompared with those in patients with sinus rhythm, the AF patients had significantly increased left and right atrial diameters and mRNA levels of MMP-3, -7, -9 and TIMP-1, -2, -3, -4 (P<0.01). MMP-1 expression also showed an increase in AF patients, but the difference was no statistically significant from that in patients with sinus rhythm.
CONCLUSIONThe expressions of MMP-1, -3, -7, -9 and TIMP-1, -2, -3, -4 increase in fibrillating atrial tissue, which may contribute to atrial structural remodeling and atrial dilatation in AF patients.
