Role of matrix metalloproteinase in transformation of subdural effusion into chronic subdural hematoma.
- Author:
Zhi-fei WANG
1
;
Da-guang LIAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Chronic Disease; Female; Hematoma, Subdural; enzymology; etiology; Humans; Male; Matrix Metalloproteinase 2; metabolism; Matrix Metalloproteinase 9; metabolism; Middle Aged; Subdural Effusion; complications; enzymology
- From: Journal of Southern Medical University 2010;30(5):1188-1189
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the role of matrix metalloproteinase (MMP) in the transformation of subdural effusion into chronic subdural hematoma.
METHODSThe clinical data of 8 patients with subdural effusion that transformed into chronic subdural hematoma were collected and MMP-2 and MMP-9 levels were detected in the sudural effusion, chronic subdural hematoma and capsules of hematoma using gelatin-zymography.
RESULTSMMP-2 and MMP-9 increased significantly in chronic subdural hematoma as compared with those in subdural effusion (P<0.01), and their levels were also significantly higher in the outer membrane than in the inner membrane of hematoma.
CONCLUSIONSubdural effusion is a risk factor for the occurrence of chronic subdural hematoma, in which process MMP plays a role as the promoting factor acting primarily in the outer membrane of the hematoma.
