Value of tumor markers in the cerebrospinal fluid in the diagnosis of meningeal carcinomatosis.
- Author:
Qiang SHI
1
;
Chuan-qiang PU
;
Wei-ping WU
;
Xu-sheng HUANG
;
Sheng-yuan YU
;
Cheng-lin TIAN
;
De-hui HUANG
;
Jia-tang ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; cerebrospinal fluid; diagnosis; Adult; Aged; Antigens, Neoplasm; cerebrospinal fluid; Biomarkers, Tumor; cerebrospinal fluid; CA-125 Antigen; cerebrospinal fluid; CA-19-9 Antigen; cerebrospinal fluid; Carcinoembryonic Antigen; cerebrospinal fluid; Female; Humans; Keratin-19; cerebrospinal fluid; Male; Membrane Proteins; cerebrospinal fluid; Meningeal Neoplasms; cerebrospinal fluid; diagnosis; Middle Aged; Young Adult
- From: Journal of Southern Medical University 2010;30(5):1192-1194
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the diagnostic value of tumor markers in the cerebrospinal fluid (CSF) for meningeal carcinomatosis (MC).
METHODSTwenty-one MC patients (including 13 adenocarcinoma and 8 non-adenocarcinoma patients), 72 patients with tuberculous meningitis (TBM) and 23 with primary intracerebral tumors (PIT) were enrolled in this study. Blood and CSF tumor markers including CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, AFP and NSE were measured by Roche E170 electrochemiluminescence analyzer and sandwich assay.
RESULTSCSF tumor markers CEA, CA125, CA199 and CYFRA21-1 and the serum tumor markers CEA, CA125, CA153, CA199 and AFP were significantly higher in MC group than in the other two groups. CSF CEA and CA15-3 were significantly higher in adenocarcinoma MC than in non-adenocarcinoma MC patients, but no significant differences were found in the serum tumor markers between the two groups (P>0.05). CSF tumor markers including CEA, CA125, CA15-3, CA72-4 and CYFRA21-1 were positively correlated to the serum tumor markers (P<0.05). CA199 was positively correlated to the disease course (P<0.05), and age was not correlated to any of the indexes (P>0.05).
CONCLUSIONDetection of the tumor markers in the CSF, especially CEA, CA125, CA19-9 and CYFRA21-1, may help in the early diagnosis of MC. CEA and CA15-3 can serve as indicators for differential diagnosis of adenocarcinoma and non-adenocarcinoma.
