Relation between insulin resistance and glutamic acid decarboxylase antibody titers in latent autoimmune diabetes in adults.
- Author:
Xia LI
1
;
Gan HUANG
;
Xiang YAN
;
Lin YANG
;
Zhi-guang ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Autoantibodies; blood; Autoimmune Diseases; diagnosis; immunology; Diabetes Mellitus, Type 2; diagnosis; immunology; Female; Glutamate Decarboxylase; immunology; Humans; Insulin Resistance; Islets of Langerhans; immunology; physiology; Male; Middle Aged
- From: Journal of Southern Medical University 2010;30(6):1247-1249
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relation between insulin resistance and glutamic acid decarboxylase antibody (GAD-Ab) titers in latent autoimmune diabetes in adults (LADA).
METHODSThe patients with phenotypic type 2 diabetes were screened for GAD-Ab positivity, and the 141 positive patients were divided into two subgroups according to the GAD-Ab titer, namely the high-titer group (LADA-1 subtype) and low-titer group (LADA-2 subgroup). The clinical features and insulin resistance were compared between the two groups. Insulin resistance was calculated by HOMA 2 software, and GAD-Ab and C peptide were determined with radioligand and radioimmune assay, respectively.
RESULTSCompared with low-titer LADA patients, the patients with high titers had younger age of onset, lower BMI, higher HbA1c level, and worse fasting and postprandial C peptide levels. The insulin resistance index by HOMA 2 was significantly lower in LADA-1 group than in LADA-2 group (1.6-/+1.1 vs 2.1-/+1.1, P=0.001). The HOMA2-IR index showed a negative correlation to GAD-Ab titer.
CONCLUSIONThe degree of insulin resistance is correlated to GAD-Ab titers in LADA, and low titer patients have higher insulin resistance level.
