Correlation between Expression of Signal Transducer and Activator of Transcription 3 and Pituitary Adenoma Subtypes.

Yong-hui Jiao; Xiao-hai Liu; Cong-xin Dai; Feng Cai; Ren-zhi Wang

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Correlation between Expression of Signal Transducer and Activator of Transcription 3 and Pituitary Adenoma Subtypes.

Author: Yong-hui JIAO ¹ ; Xiao-hai LIU ¹ ; Cong-xin DAI ¹ ; Feng CAI ² ; Ren-zhi WANG ¹
Author Information

1. Department of Neurosurgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
2. Department of Neurosurgery,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China.
Publication Type:Journal Article
MeSH: Adenoma; Follicle Stimulating Hormone; Human Growth Hormone; Humans; Immunohistochemistry; Pituitary Neoplasms; Real-Time Polymerase Chain Reaction; STAT3 Transcription Factor; Signal Transduction
From: Acta Academiae Medicinae Sinicae 2015;37(6):693-697
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the correlation between signal transducer and activator of transcription 3 (STAT3) expression and pituitary adenoma subtypes.
METHODThe STAT3 expression profiles in different pituitary adenomas from 74 patients were determined using quantificational real-time polymerase chain reaction,Western blot,and immunohistochemistry.
RESULTSExpression of STAT3 was observed in all pituitary adenoma subtypes. The STAT3 expression level was highest in growth hormone adenoma when compared with other tumors including prolactin,follicle-stimulating hormone/luteinizing hormone-secreting adenoma,and adrenocorticotrophic hormone-secreting adenoma. The follicle-stimulating hormone/luteinizing hormone adenomas exhibited the lowest STAT3 expression levels.
CONCLUSIONSTAT3 is differentially expressed in pituitary adenoma subtypes, suggesting the cell-specific features of STAT3 regulation,although further investigations are still warranted to clarify the underlying mechanisms.