KLF17 Expression in Colorectal Carcinoma and Its Clinical Significance.
- Author:
He-li GAO
1
;
Na ZHOU
1
;
Zhao SUN
1
;
Xue-lin DOU
1
;
Mei GUAN
1
;
Chun-mei BAI
1
Author Information
- Publication Type:Journal Article
- MeSH: Colorectal Neoplasms; Disease-Free Survival; Humans; Immunohistochemistry; Prognosis; Transcription Factors
- From: Acta Academiae Medicinae Sinicae 2016;38(1):69-72
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo detect KLF17 expression in colorectal carcinoma (CRC) and to evaluate its effect on the prognosis of colorectal carcinoma.
METHODSImmunohistochemistry was performed to detect the expression of KLF17 in CRC and matched pericarcinous tissue,and the relationship between KLF17 expression and disease-free survival (DFS) was analyzed.
RESULTSOf 73 CRC patients, KLF17 expression was positive in 32 patients and negative in 41 patients. KLF17 expression rate was significantly lower in CRC tissue than in pericarcinous tissue (χ(2)=12.418, P=0.001). The DFS of KLF17-positive stage III colon cancer patients was (56.3±7.2) months (95% CI: 42-70 months), which was significantly longer than that [(32.3±5.5) months (95% CI: 22-43 months)] of KLF17-negative patients (P=0.039).
CONCLUSIONKLF17 expression decreases in CRC tissue, and a positivie KLF17 expression predicts a better prognosis in stage III CRC patients.
