Pathogenesis of Castleman's Disease.
10.3881/j.issn.1000-503X.2016.01.022
- Author:
Lu ZHANG
1
;
Jian LI
1
Author Information
1. Department of Hematology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
- Publication Type:Journal Article
- MeSH:
Castleman Disease;
Herpesvirus 8, Human;
Humans;
Interleukin-6
- From:
Acta Academiae Medicinae Sinicae
2016;38(1):118-121
- CountryChina
- Language:English
-
Abstract:
Castleman's disease (CD) is a rare lymphoproliferative disorder that comprises at least two distinct clinical subtypes (unicentric and multicentric). Three pathologic variants (hyaline vascular variant, plasma cell variant, and mixed variant) have been recognized. In addition to interleukin-6 and human herpes virus 8, some other cytokines and viruses may also be involved in the pathogenesis of CD. This review summarizes the recent advances in the underlying pathogenesis of CD, with an attempt to provide evidence for new treatment options that may change the current treatment strategies and improve patients' outcomes.
