Correlation between Ultrasound-guided Diffuse Optical Tomography and Hypoxia-inducible Factor-1Α of Breast Cancer.
10.3881/j.issn.1000-503X.2016.03.018
- Author:
Si-hua NIU
1
;
Qing-li ZHU
1
;
Yu-xin JIANG
1
;
Jia-an ZHU
2
;
Meng-su XIAO
1
;
Shan-shan YOU
1
;
Wei-xun ZHOU
3
;
Yu XIAO
3
Author Information
1. 1Department of Ultrasound,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
2. 2Department of Ultrasound,Peking University People’s Hospital,Beijing,100044,China
3. 3Department of Pathology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
- Publication Type:Journal Article
- MeSH:
Breast Neoplasms;
diagnostic imaging;
metabolism;
Female;
Humans;
Hypoxia-Inducible Factor 1, alpha Subunit;
metabolism;
Neovascularization, Pathologic;
Tomography, Optical;
Ultrasonography, Mammary
- From:
Acta Academiae Medicinae Sinicae
2016;38(3):341-345
- CountryChina
- Language:English
-
Abstract:
Objective To investigate the correlation between ultrasound-guided diffuse optical tomography (US-DOT) and hypoxia-inducible factor-1Α (HIF-1Α) of breast cancer. Methods Totally 69 patients with pathologically confirmed breast cancer underwent preoperative conventional breast ultrasonography examinations and US-DOT at Peking Union Medical College Hospital From October 2007 to February 2010 were enrolled in this study.After surgery,immunohistochemical staining of HIF-1Α and CD34 were performed,and the differences of total hemoglobin concentration (THC) and microvessel density (MVD) between HIF-1Α positive and negative groups were analyzed. Results HIF-1Α was positive in 12 cases (17.4%) and negative in 57 cases (82.6%). The average THC and MVD of HIF-1Α-positive cases were (274.763±77.661) Μmol/L and (33.8±10.8)/0.2 mm(2) respectively. The average THC and MVD of HIF-1Α-negative cases were (228.059±65.760)Μmol/L and (28.4±7.4)/0.2 mm(2). MVD(t=2.049,P=0.04) and THC(t=2.167,P=0.034) of HIF-1Α-positive group were significantly higher than those of HIF-1Α-negative group. Conclusions HIF-1Α can promote tumor angiogenesis and thus increase the blood supply and THC. As an indicator of tumor blood supply,THC can indirectly reflect the angiogenic activity of breast cancer.
