Research Advances in CKLFSF-like MARVEL Transmembrane Domain Containing Member 3.
10.3881/j.issn.1000-503X.2016.03.022
- Author:
Feng-zhan HU
1
;
Zheng-zuo SHENG
1
;
Cai-peng QIN
1
;
Tao XU
1
Author Information
1. Department of Urology,Peking University People’s Hospital,Beijing 100044,China
- Publication Type:Journal Article
- MeSH:
Cell Transformation, Neoplastic;
Chemokines;
genetics;
physiology;
Down-Regulation;
Humans;
Leukocytes, Mononuclear;
MARVEL Domain-Containing Proteins;
genetics;
physiology;
Male;
Neoplasms;
pathology
- From:
Acta Academiae Medicinae Sinicae
2016;38(3):360-363
- CountryChina
- Language:English
-
Abstract:
CKLF-like MARVEL transmembrane domain containing member/chemokine-like factor super family member (CKLFSF/CMTM) is a novel tumor suppressor gene. CMTM3 is broadly expressed in normal human tissues and evolutionary conserved,especially in testis,spleen,and some cells of peripheral blood mononuclear cells. However,its expression is undetectable or down-regulated in most carcinoma cell lines and tissues. Restoration of CMTM3 may inhibit the proliferation,migration,and invasion of carcinoma cells. Although the exact mechanism of its anti-tumor activity remains unclear,CKLFSF3/CMTM3 is closely connected with immune system and associated with sex during tumorigenesis. The study advances of CKLFSF3/CMTM3 are elaborated in this review as CMTM3 may be a new target in the gene therapies for tumors,especially genitourinary tumors,while further studies on CMTM3 and its anti-tumor mechanisms are warranted.
