Clinical efficacy of mouse nerve growth factor in treatment of occupational hand-arm vibration disease.
- Author:
Chunyue FAN
1
;
Yanyan WANG
1
;
Ying ZHANG
1
;
Li LANG
1
;
Xiaofeng DENG
1
;
Ying CHENG
1
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Hand-Arm Vibration Syndrome; drug therapy; Humans; Mice; Nerve Growth Factor; pharmacology; Occupational Diseases; Treatment Outcome; Vibration
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2014;32(12):924-927
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the efficacy of mouse nerve growth factor (mNGF) in treating occupational hand-arm vibration disease (HAVD).
METHODSSixty-four patients with HAVD were equally and randomly divided into treatment group and control group. The control group was given Salvia miltiorrhiza Bunge and deproteinized extract of calf blood to improve circulation, and also given methylcobalamin tablets and vitamin B6 for neurotrophic treatment. In addition to the above treatments for the control group, the treatment group was also given 30 µg/d mNGF by intramuscular injection for two courses (4 weeks for each course) with a 15-day interval.
RESULTSBoth the treatment group and the control group showed significant improvements in clinical symptoms and signs (hand numbness and pain, and reduced senses of touch, pain, and vibration), cold water loading test (CWLT), and electroneuromyography (ENMG) after treatments (P < 0.05). And the treatment group had significantly more improvements than the control group (P < 0.05).
CONCLUSIONmNGF can significantly improve hand numbness and pain, reduced senses of touch, pain, and vibration, CWLT, and ENMG, so it has better clinical effect and safety in treating HAVD. Early diagnosis and treatment can improve the outcome of patients with HAVD.
