Anti-fatigue effect of Renshen Yangrong decoction in mice.
- Author:
Yan-zhi CHEN
1
;
Fei LIN
;
Ping-ping LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Urea Nitrogen; Drugs, Chinese Herbal; pharmacology; therapeutic use; Fatigue; blood; drug therapy; Glutamic Acid; blood; Glycogen; metabolism; Liver; drug effects; metabolism; Mice; Organ Size; drug effects; Spleen; drug effects; metabolism; pathology; Swimming; Thymus Gland; drug effects; metabolism; pathology; Time Factors
- From: Chinese journal of integrative medicine 2011;17(10):770-774
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo explore the anti-fatigue effect of Renshen Yangrong Decoction (RYD): in mice.
METHODSOne hundred Kunming mice were randomly divided into 5 groups with 20 mice in each: group. The negative control group was treated with distilled water, the positive control group was treated with Shiyiwei Shenqi Tablet (, 1.0 g/kg), the high-, medium- and low-dose RYD groups were treated with 42.0, 21.0 and 10.5 g/kg of RYD daily, respectively, by gastric infusion. At the end of the 7-day treatment, loaded swimming time, organ wet weight and coefficient, serum glucose, urea nitrogen, and hepatic glycogen levels were determined. The outcomes were compared among groups.
RESULTSAs compared with the negative: control group, the loaded swimming time was significantly increased in the positive control group, specifically the medium- and high-dose RYD groups (P<0.01). In addition, the wet weights and coefficients of the spleen and thymus, and the serum glucose and hepatic glycogen contents were increased, whereas serum urea nitrogen level was significantly decreased in the positive control group and the high dose RYD group (P<0.05 or P<0.01).
CONCLUSIONRYD showed an anti-fatigue effect in mice.
