Efficacy of ursodeoxycholic acid combined with Tongdan Decoction () on immunological indices and histopathological changes in primary biliary cirrhosis patients.
- Author:
Guang-Dong TONG
1
;
Hai-Hong TANG
;
Chun-Shan WEI
;
Ying-Jie CHEN
;
Jin-Song HE
;
Xiao-Zhou ZHOU
;
Ying-Jun ZHENG
;
Da-Qiao ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Antigens, CD; blood; Biomarkers; Drug Therapy, Combination; Drugs, Chinese Herbal; therapeutic use; Female; Humans; Immunoglobulin G; blood; Inflammation; blood; complications; Liver Cirrhosis, Biliary; blood; drug therapy; immunology; pathology; Male; Middle Aged; Ursodeoxycholic Acid; therapeutic use
- From: Chinese journal of integrative medicine 2012;18(1):16-22
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo observe the efficacy of ursodeoxycholic acid (UDCA) combined with Tongdan: Decoction () on immunological indices and histopathological changes in patients with primary biliary cirrhosis (PBC) of IIor III histological stage.
METHODSSixty PBC patients were assigned randomly and equally: to the control group treated with UDCA alone and the treatment group treated with UDCA combined with Tongdan Decoction. The immunological indices and histopathological changes were detected before and after 24-week treatment, and the follow-up lasted for 1-3 years.
RESULTSAfter 24-week treatment, CD4(+)CD28(-) in the peripheral blood was lowered and CD4(+)CD25(+) was increased in both groups, and better effect was shown in the treatment group (P<0.01). The levels of IgM, IgG, and IgA decreased markedly after 96-week treatment in the treatment group (P< 0.05, P< 0.01), while in the control group, only the latter two showed significant decrease after 148 week (all P<0.05). At the end of the 3-year follow-up, the medians of histopathological
CONCLUSIONCombined therapy of Tongdan Decoction and UDCA showed a better therapeutic effect: than UDCA monotherapy on PBC, especially in improving immunological indices and histopathological hepatic changes.
