Detection and clinical features of human rhinovirus in hospitalized children with acute respiratory tract infection in eastern areas of Guangdong province
10.3760/cma.j.issn.0254-6450.2012.10.019
- VernacularTitle:粤东地区2008-2010年急性呼吸道感染住院儿童中人鼻病毒检出及临床分析
- Author:
Jin-Hua FENG
1
,
2
;
Guang-Yu LIN
;
Xue-Dong LU
;
Chuang-Xing LIN
;
Pai-Zhen CHEN
;
Xiao-Hua ZHOU
;
Xiao-Ying CAI
;
Qing-Bin LIANG
;
Lian MA
Author Information
1. 515041 广东省汕头大学医学院第二附属医院儿科
2. 郑州市儿童医院
- Keywords:
Rhinovirus;
Acute respiratory infection;
Children;
Epidemic characteristics
- From:
Chinese Journal of Epidemiology
2012;33(10):1075-1078
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevalence and clinical features of human rhinovirus (HRV) infection in hospitalized children with acute respiratory (ARI) in eastern areas of Guangdong province from 2008 to 2010.Methods From Oct.2008 through Sep.2010,nasopharyngeal aspirates were collected prospectively,from hospitalized children with acute lower respiratory tract infection at the Second Hospital,affiliated to the Shantou University Medical College.Multiplex PCR was applied to detect ten kinds of viruses including HRV,RSV in the hospitalized children with respiratory tract infection.Clinical data on HRV-positive cases or RSV-positive cases were collected and analyzed.Results Among all the 1335 specimens,124 were confirmed as HRV-positive cases (9.3％),with IVA-positive rate as the highest (25.1％),followed by RSV-positive rate (15.1％).HRV infection occurred sporadically around the year,with the highest HRV-positive rate seen in spring 2009 and autumn in 2010.Symptoms,signs,chest X-ray,leukocyte count and CRP count did not differ between patients with co-infection or single HRV infection.Clinical symptoms or signs were similar between those with single HRV infection or single RSV infection in children,but the single RSV infected children were more frequently seen with wheeze and cough.28.4％ of the single RSV infected children had bronchiolitis while 10.7％ of single HRV infected children were seen (x2=0.281,P=0.596).Conclusion HRV was a relatively common cause for acute respiratory infections in the eastern areas of Guangdong province.The highest HRV-positive rate was slightly different in different years.Infants and young children were generally susceptible to rhinovirus infection.Bronchiolitis,wheeze and cough associated with HRV infection happened less than those caused by RSV.
