Clinical features of inhaled and blood-borne Staphylococcus aureus pneumonia and analysis of antibiotic resistance of the pathogen in children.
- Author:
Guang-Li ZHANG
1
,
2
;
Ru LIU
;
Hui ZHANG
;
Ying LI
;
Dong-Wei ZHANG
;
Jun-Qi LI
;
Si-Ying ZHANG
;
Jun ZHU
;
Zheng-Xiu LUO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Age Factors; Blood-Borne Pathogens; isolation & purification; Child; Child, Preschool; Drug Resistance, Bacterial; Female; Humans; Infant; Male; Pneumonia, Staphylococcal; drug therapy; microbiology; Retrospective Studies
- From: Chinese Journal of Contemporary Pediatrics 2014;16(10):979-983
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the clinical manifestations between inhaled and blood-borne Staphylococcus aureus pneumonia (SAP) and the antibiotic resistance between the isolates of inhaled and blood-borne Staphylococcus aureus.
METHODSThe clinical data of 44 pediatric SAP cases in the Children′s Hospital, Chongqing Medical University from January 2008 to December 2013 were retrospectively analyzed. Twenty-four cases were identified as inhaled SAP, and 20 cases as blood-borne SAP.
RESULTSInhaled SAP was more common in children younger than 3 years of age, while blood-borne SAP was more prevalent in children older than 6 years of age. Patients with inhaled SAP had significantly higher incidence rates of cough, wheeze, moist rales, dyspnea and empyema than those with blood-borne SAP (P<0.05). The patients with blood-borne SAP were more vulnerable to severe fever, unconsciousness, dysfunction of liver and kidney, pyogenic osteomyelitis, septic arthritis, sepsis, and abscess of skin and soft tissues (P<0.05). Inhaled SAP isolates had significantly higher rates of resistance to amoxicillin/clavulanic acid, oxacillin, and cefoxitin than blood-borne SAP isolates (P<0.05), while the latter had a higher rate of resistance to cotrimoxazole (P<0.05).
CONCLUSIONSInhaled SAP often occurs in children younger than 3 years of age, and the respiratory manifestations are commonly seen. Blood-borne SAP often occurs in children older than 6 years of age, with the infectious-toxic symptoms that result in multiple organ infection and dysfunction. The isolates of inhaled and blood-borne SAP have different antibiograms.