Serum tumor necrosis factor-α, interleukin -6 and galctin-3 concentrations in children with Mycoplasma pneumoniae pneumonia.
- Author:
Fang TIAN
1
;
Bo HAN
;
Mei DUAN
Author Information
- Publication Type:Journal Article
- MeSH: Child; Child, Preschool; Female; Galectin 3; blood; Humans; Interleukin-6; blood; Male; Pneumonia, Mycoplasma; etiology; immunology; Tumor Necrosis Factor-alpha; blood
- From: Chinese Journal of Contemporary Pediatrics 2014;16(10):1001-1004
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the changes in serum tumor necrosis factor-α (TNF- α), interleukin-6 (IL-6) and galctin-3 (Gal-3) concentrations in children with Mycoplasma pneumoniae pneumonia (MPP), and their roles in MPP.
METHODSSerum TNF-α, IL-6 and Gal-3 concentrations were measured using double antibody sandwich ELISA in 48 children with acute MPP (severe: 21 cases; mild: 27 cases) and in 30 healthy children (control group).
RESULTSSerum concentrations of TNF-α, IL-6 and Gal-3 in both the severe and mild groups were significantly higher than in the control group before treatment. The concentrations of the three indexes in the severe group were significantly higher than in the mild group. Serum concentrations of the three indexes decreased significantly after treatment in both groups.
CONCLUSIONSSerum TNF-α, IL-6 and Gal-3 play important roles in the occurrence and development of pediatric MPP and their levels are associated the severity of this disorder.
