Association between gene polymorphism of CD40 gene and coronary artery lesion in Kawasaki disease.
- Author:
Shou-Chao CHENG
1
;
Yan-Yang CHENG
;
Jin-Long WU
Author Information
- Publication Type:Journal Article
- MeSH: CD40 Antigens; genetics; Case-Control Studies; Child; Child, Preschool; Coronary Artery Disease; genetics; Female; Humans; Infant; Male; Mucocutaneous Lymph Node Syndrome; genetics; Polymorphism, Single Nucleotide
- From: Chinese Journal of Contemporary Pediatrics 2014;16(10):1025-1028
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the association between two single nucleotide polymorphisms (rs4810485 and rs1535045 in CD40 gene) and Kawasaki disease (KD) in Han Chinese children.
METHODSA case-control study was performed on 184 children with KD and 206 normal controls. The polymorphisms of two SNPs in CD40 gene were detected using PCR-RFLP.
RESULTSThere were no significant differences in the genotype distribution and allele frequency of SNP rs4810485 in CD40 gene between the KD and normal groups (P>0.05). The genotype distribution of SNP rs1535045 in CD40 gene in the KD group was significantly different from the control group (P<0.05). T allele of SNP rs1535045 was shown as a risk factor for development of KD (OR=1.592, 95%CI: 1.182-2.144, P=0.004). There were no association between the polymorphisms of the two SNPs and coronary artery lesions (P>0.05).
CONCLUSIONSSNP rs1535045 may be associated with the development of KD in Han Chinese children, while SNP rs4810485 may not.
