Roles of CD4+CD25+Foxp3+ regulatory T cells and IL-33 in the pathogenesis of asthma in children.
- Author:
Zhen-Zhen PAN
1
;
Ling LI
;
Yun GUO
;
Jian HE
Author Information
- Publication Type:Journal Article
- MeSH: Asthma; etiology; immunology; Child; Child, Preschool; Female; Forkhead Transcription Factors; analysis; Humans; Infant; Interleukin-2 Receptor alpha Subunit; immunology; Interleukin-33; Interleukins; physiology; Male; T-Lymphocytes, Regulatory; physiology
- From: Chinese Journal of Contemporary Pediatrics 2014;16(12):1211-1214
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the roles of CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg) and IL-33 in the pathogenesis of asthma in children.
METHODSFlow cytometry was used to detect peripheral blood CD4(+)CD25(+)Foxp3(+)Treg proportion in CD4(+)T lymphocytes in.45 children with asthma, 50 children with wheezing caused by respiratory syncytial virus infection and 40 healthy children. Serum levels of IFN-γ, IL-4, IL-5 and IL-33 were measured using ELISA.
RESULTSThe level of peripheral blood CD4(+)CD25(+)Foxp3(+)Treg in the asthma group was significantly lower than in the wheezing and control groups (P<0.05). In contrast, serum levels of IL-33 in the asthma group was significantly higher than in the wheezing and control groups (P<0.05). Peripheral blood CD4(+)CD25(+)Foxp3(+)Treg level was negatively correlated with serum IL-33 level in the asthma group(r=-0.156, P<0.01).
CONCLUSIONSCD4(+)CD25(+)Foxp3(+)Treg may interact with IL-33 in the pathogenesis of childhood asthma.
