Clinical features of childhood hemophagocytic syndrome and its association with human parvovirus B19 infection.
- Author:
Ying-Chao WANG
1
;
Dong-Jie LIU
;
Li-Na MA
;
Man-Ju LIU
;
Guang-Yao SHENG
;
Xiao-Ming ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Antibodies, Viral; analysis; Child; Child, Preschool; DNA, Viral; analysis; Female; Humans; Infant; Lymphohistiocytosis, Hemophagocytic; etiology; Male; Parvoviridae Infections; complications; Parvovirus B19, Human
- From: Chinese Journal of Contemporary Pediatrics 2015;17(1):26-30
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of childhood hemophagocytic syndrome (HPS) with human parvovirus B19 (HPVB19) infection, and to analyze the clinical features of this disease.
METHODSELISA and quantitative real-time PCR were used to detect HPVB19-IgM, HPVB19-IgG and HPVB19-DNA in 65 children with HPS (HPS group) and 65 healthy children (control group). The HPS group was divided into HPVB19-infected (n=14) and non-infected (n=51) groups according to the detection results of HPVB19-DNA. The clinical data of two groups were compared.
RESULTSThe positive rate of HPVB19-IgM in the HPS group (26%, 17/65) was significantly higher than that in the control group (9%, 6/65) (P=0.011), and there was no significant difference in the positive rate of HPVB19-IgG between the HPS (38%, 25/65) and control groups (29%, 19/65) (P=0.266). The infection rate of HPVB19 in the HPS group (22%, 14/65) was significantly higher than that in the control group (3%, 2/65) (P=0.001). Compared with the non-infected group, the HPVB19-infected group had significantly lower platelet count and hemoglobin level on admission, significantly more severe liver function damage, a significantly earlier onset time, and a significantly longer course of disease (P<0.05).
CONCLUSIONSThe pathogenesis of HPS may be associated with HPVBl9 infection. HPVBl9-infected children with HPS have more acute onset, more severe clinical manifestations, and a longer disease duration.