Serum levels of 25-hydroxyvitamin D in children with autism spectrum disorders.
- Author:
Lin DU
1
;
Ling SHAN
;
Bing WANG
;
Jun-Yan FENG
;
Zhi-Da XU
;
Fei-Yong JIA
Author Information
- Publication Type:Journal Article
- MeSH: Child; Child Development Disorders, Pervasive; blood; Child, Preschool; Chromatography, High Pressure Liquid; Female; Humans; Infant; Male; Vitamin D; analogs & derivatives; blood; Vitamin D Deficiency; epidemiology
- From: Chinese Journal of Contemporary Pediatrics 2015;17(1):68-71
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo examine serum 25-hydroxyvitamin D levels in children with autism spectrum disorders (ASD) and to explore the relationship between vitamin D level and ASD.
METHODSSerum levels of 25-hydroxyvitamin D levels were determined by the HPLC-MS/MS method in 117 children with newly diagnosed ASD and 109 healthy controls. Vitamin D status were classified into normal (>30 ng/mL), insufficiency (10-30ng/mL) and deficiency (<10 ng/mL) according to 25-hydroxyvitamin D levels.
RESULTSSerum level of 25-hydroxyvitamin D (19±9 ng/mL)in children with ASD was significantly lower than that in healthy controls (36±13 ng/mL; P<0.01). The rate of vitamin D insufficiency plus deficiency in the ASD group was significantly higher than in the control group (89.7% vs 52.3%; P<0.01).
CONCLUSIONSVitamin D insufficiency or deficiency is common in children with ASD and might be as one of the environmental or genetic factors for ASD.
