Influence of Shenlian decoction on early lesion of atherosclerosis in rats.
- Author:
Lina CHEN
1
;
Yujie LI
;
Qing YANG
;
Xiaogang WENG
;
Liyun ZHOU
;
Xiaoxin ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Atherosclerosis; blood; drug therapy; pathology; prevention & control; Disease Models, Animal; Drugs, Chinese Herbal; administration & dosage; Humans; Interleukin-6; blood; Male; Protective Agents; administration & dosage; Random Allocation; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; blood
- From: China Journal of Chinese Materia Medica 2011;36(1):66-71
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish the atherosclerosis models (AS) in rats and observe the change process of AS and Shenlian decoction's pharmacological effect.
METHODTwo hundreds and forty rats were randomly divided into blank control group, model group, positive medicine group, the high-dose, middle dose and low-dose Shenlian decoction groups. Vascular pathological changes were observed by the methods of HE stain. The levels of TC, TG, LDL-C, HDL-C, NO in serum were determined respectively by enzyme colorimetric, clear and nitrate reductase methods. ET, TXB2, 6-keto-PGF1 alpha, TNF-alpha, IL-6 and IL-8 levels in serum were detected by radioimminoassay.
RESULTCompared with the model group, vascular lesion of different doses of Shenlian decoction groups were significantly improved, the TG, NO, TXB2 levels in serum were significantly lower (P < 0.05), while high-dose Shenlian decoction can significantly reduce TNF-alpha, IL-6, IL-8 levels in serum (P < 0.05).
CONCLUSIONShenlian decoction can inhibit the formation and development of AS by regulating blood lipids, improving endothelial function and reducing inflammatory factors release.
