Experimental study on Qi deficiency and blood stasis induced by muti-factor stimulation in rats.
- Author:
Jianxun REN
1
;
Chengren LIN
;
Jianxun LIU
;
Li XU
;
Min WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Circulation; drug effects; Blood Pressure; drug effects; Blood Viscosity; drug effects; Disease Models, Animal; Drugs, Chinese Herbal; administration & dosage; Hemorheology; Humans; Lipids; blood; Male; Qi; Random Allocation; Rats; Yin Deficiency; blood; drug therapy; etiology; physiopathology
- From: China Journal of Chinese Materia Medica 2011;36(1):72-76
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEAnimal model of Qi deficiency and blood stasis was established by muti-factor stimulation in rats.
METHODHealthy SD rats were chronically stimulated randomly by muti-factor methods (chronic sleep deprivation and feed with moderately high lipid and sugar food). Then the indices of hemorheology, plasma total lipids, vasoactive molecules, blood pressure (BP) and ventricular pressure (VP) were measured.
RESULTThe results as well as the analysis of etiology and pathology suggested that model rats could objectively reflect the clinical characteristics of Qi deficiency and blood stasis syndrome. Blood viscosity at low level, plasma content of angiotensin II (Ang II) and endothelin (ET) significantly increased in model rats, while BP and VP significantly decreased (P < 0.05). On the other hand, Buyang Huanwu decoction could lower down the level of AngII in serum and blood viscosity at low level in rats induced by some stimulus, whereas BP and VP elevated significantly (P < 0.05).
CONCLUSIONAnimal model of Qi deficiency and blood stasis induced by muti-factor stimulation including chronic sleep deprivation and feed with moderately high lipid and sugar food could facilitate further study on blood stasis syndrome and screening of Chinese herbal drugs in promoting blood circulation and removing blood stasis.
