Regulative mechanism of Chinese herbal medicine on cell signaling pathway in kidney.
- Author:
Chaojun WANG
1
;
Yigang WAN
;
Xunyang LUO
;
Chenhui DOU
;
Qing FENG
;
Qiaojing YAN
;
Jian YAO
Author Information
1. Nanjing Drum Tower Hospital Clinical College of Traditional Chinese Medicine and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China. wachjun2000@163.com
- Publication Type:Journal Article
- MeSH:
Animals;
Apoptosis;
drug effects;
Cell Differentiation;
drug effects;
Cell Proliferation;
drug effects;
Drugs, Chinese Herbal;
pharmacology;
Humans;
Kidney;
cytology;
drug effects;
metabolism;
Signal Transduction;
drug effects
- From:
China Journal of Chinese Materia Medica
2011;36(1):85-91
- CountryChina
- Language:Chinese
-
Abstract:
In kidney, the role of cell proliferation, differentiation, apoptosis, inflammatory mediators and cytokines expression is closely related with cell signaling pathways, including tyrosine kinase pathway, transforming growth factor-beta/Smad pathway, Rho/Rho-associated coiled-coil forming protein kinase pathway, phosphoinositol pathway, cyclic nucleotide pathway, nuclear factor kappaB pathway and so on. Some Chinese herbs and their extracts, such as rhubarb and triptolide, as well as some Chinese herbal prescriptions, such as astragalus-angelica mixture and Chailing decoction, not only could ameliorate proliferation, differentiation and apoptosis of renal cell by regulating cell signaling pathways, but also could control target gene transcription, expression and its biological effects through inhibiting the phosphorylation of key signaling molecules.
