Preparation of xiongbing microemulsion and its quality evaluation.
- Author:
Lisheng WANG
1
;
Qi GUO
;
Yingfeng ZHANG
;
Zongfeng SHI
Author Information
- Publication Type:Journal Article
- MeSH: Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; methods; Drug Stability; Drugs, Chinese Herbal; chemistry; Emulsions; chemistry; Particle Size; Solubility
- From: China Journal of Chinese Materia Medica 2011;36(2):142-146
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the preparation of xiong-bing microemulsion (XB ME) and its quality evaluation.
METHODXB ME was prepared by using the methods of titration to prepare the Pseudo-ternary phase diagram. The stability and size distribution of XB ME were tested. The contents of TMP and FA in ME were determined by HPLC method.
RESULTThe character of XB ME was stable. The average diameter was 17.6 nm, and a uniform distribution of particle size were achieved. The solubility of TMP in ME was 2.6 g x L(-1), the methodological average recovery was 97.0% with RSD of 1.5% (n=6); The solubility of FA in ME was 0.3 g x L(-1), the methodological average recovery was 95.9% with RSD of 1.9% (n=6).
CONCLUSIONThe results indicated that the quality of XB ME was stable. The method to determine the contents of TMP and FA was accurate and reliable.
