Cyclic nucleotides phosphodiesterase activity in a rat lung model of asthma
- Author:
Yan-Hua SONG
1
;
Ji-Qiang CHEN
;
Han-Liang ZHOU
Author Information
1. College of Medical Science, Zhejiang University, Hangzhou 310031, China.
- Publication Type:Journal Article
- From:
Journal of Zhejiang University. Medical sciences
2002;31(2):127-130
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To assess the change of cGMP-PDE and cAMP-PDE activity in a rat lung model of asthma. METHODS: cGMP-PDE and cAMP-PDE activity were determined by HPLC. RESULTS: Both cAMP-PDE activity and cGMP-PDE activity in the lung tissue of antigen-challenged rats were higher than that from the normal rats (P <0.05). CONCLUSION: In the rat lung model of asthma, cyclic nucleotides phosphodiesterase activity was elevated. This may be significant in the pathogenesis of asthma.
