The relationship between arterial blood oxygen pressure and the changes in blood biochemical indices after partial liquid ventilation in canine inhalation injury.
- Author:
Qinghong HU
1
;
Guanghua GUO
;
Wen WANG
;
Yang WANG
;
Guohui LI
;
Yong CAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Gas Monitoring, Transcutaneous; Blood Pressure; Burns, Inhalation; blood; physiopathology; therapy; Disease Models, Animal; Dogs; Female; Male; Malondialdehyde; blood; Nitric Oxide; blood; Oxygen; metabolism; Reactive Oxygen Species; blood
- From: Chinese Journal of Burns 2002;18(3):142-144
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the therapeutic effects of partial liquid ventilation on canine inhalation injury.
METHODSMongrel dogs were inflicted with steam inhalation injury and were employed as the model. Partial liquid ventilation was accomplished by slow instillation of into the lungs. The changes in blood superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO) and arterial oxygen pressure (PaO(2)) were determined.
RESULTSThe blood levels of MDA and NO at 2 postburn hours (PBHs) increased obviously but those of SOD and PaO(2) decreased significantly when compared with those before injury (P < 0.05). The blood levels of SOD, MDA, NO and PaO(2) recovered to near preinjury levels after partial liquid ventilation.
CONCLUSIONPartial liquid ventilation might be helpful in the management of inhalation injury by raising blood oxygen pressure, antagonizing lipid peroxidation and reducing the in vivo NO production.
