The influence of N-acetyl-L-cysteine on pulmonary injury and oxygen stress after smoke inhalation injury.
- Author:
Zuhong FU
1
;
Zongcheng YANG
;
Li LIU
;
Zhiyuan LIU
;
Baobin HE
;
Zhixia LIU
;
Jiangping WU
Author Information
- Publication Type:Journal Article
- MeSH: Acetylcysteine; pharmacology; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Free Radical Scavengers; pharmacology; Glutathione; metabolism; Hydrogen Peroxide; metabolism; Leukocytes; drug effects; Oxidative Stress; drug effects; Peroxidase; metabolism; Rats; Rats, Wistar; Smoke Inhalation Injury; enzymology; metabolism; pathology
- From: Chinese Journal of Burns 2002;18(3):152-154
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the influence of N-acetyl-L-cysteine (NAC) on pulmonary injury and oxygen stress caused by smoke inhalation injury.
METHODSRats inflicted with smoke inhalation injury were employed as the model. WBC in BALF (bronchoalveolar lavage fluid), MPO (myeloperoxidase) activity, hydrogen peroxide (H(2)O(2)) content, GSH (glutathione) content and total antioxidant (TAO) capacity in pulmonary tissue were determined.
RESULTSPostinjury WBC in BALF, MPO activity in pulmonary tissue and H(2)O(2) content decreased obviously after NAC treatment. But the pulmonary tissue contents of GSH and ATO increased evidently after the treatment with NAC.
CONCLUSIONNAC treatment could ameliorate pulmonary oxygen stress after smoke inhalation injury. AS a result, the pulmonary antioxidant capacity was improved.
