The role of the change in glucocorticoid receptor in stress-induced gastric ulcer in severely burned rats.

Author: Chao ZHANG ¹ ; Zongcheng YANG ; Ao LI
Author Information

1. Institute of Burn Research, Southwestern Hospital, The Third Military Medical University, Chongqing 400038, P.R. China.
Publication Type:Journal Article
MeSH: Animals; Burns; complications; metabolism; Disease Models, Animal; Male; Rats; Rats, Wistar; Receptors, Glucocorticoid; metabolism; physiology; Stomach Ulcer; complications; metabolism; Stress, Physiological; complications
From: Chinese Journal of Burns 2002;18(3):163-165
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the role of the change in glucocorticoid receptor in stress-induced gastric ulcer in severely burned rats.
METHODSWistar rats inflicted with 30% TBSA full-thickness burn were employed as the model. The dynamic postburn change in the glucocorticoid receptor in gastric mucosal tissue and gastric mucosal injury (injury index) were observed.
RESULTSThe gastric mucosal cortisol content increased as of 3 postburn hours (PBHs) and peaked at 12 PBHs. But the cytoplasmic glucocorticoid receptor content in the gastric mucosal cells decreased evidently. In addition, the gastric mucosal injury index increased obviously at 12 and 24 PBHs.
CONCLUSIONThe decrease of gastric mucosal cytoplasmic glucocorticoid receptor content might be closely related to the stress-induced gastric mucosal injury.