The influence of recombinant human growth hormones on the systemic metabolism after severe burn.
- Author:
Zhongyong CHEN
1
;
Caizhi GU
;
Zhixue WANG
;
Xiangbai YE
;
Xihua WANG
;
Huijie LI
;
Yunbiao SHEN
;
Jinxi LI
Author Information
- Publication Type:Clinical Trial
- MeSH: Adolescent; Adult; Blood Proteins; drug effects; metabolism; Burns; blood; Female; Growth Hormone; blood; pharmacology; Humans; Insulin; blood; Insulin-Like Growth Factor I; analysis; drug effects; Male; Middle Aged; Recombinant Proteins; pharmacology
- From: Chinese Journal of Burns 2002;18(3):183-185
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the influence of recombinant human growth hormones (rhGH) postburn systemic metabolism.
METHODSTwenty-four burn patients were randomly and equally divided into treatment and control groups. Same amount of rhGH (9 U/d) or isotonic saline was injected subcutaneously to respective patients during 3 approximately 17 postburn days (PBDs). Blood samples were harvested at 3, 10 and 17 PBDs for the determination of serum growth hormone, insulin-like growth factor (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), serum proteins, plasma insulin, plasma glucagons and blood glucose, which were then compared and analyzed between two the groups.
RESULTSThe serum levels of GH, IGF-1, IGFBP-3, serum prealbumin and transferrin in rhGH treatment group were evidently higher than those in control groups at 10 and 17 PBDs (P < 0.05 approximately 0.01). But there was no obvious difference in serum albumin, plasma insulin, glucagon and blood glucose (P > 0.05).
CONCLUSIONSmall dose of rhGH could promote systemic protein synthesis with no side effects on blood glucose levels.
