The significance of postburn changes in plasma levels of ICAM-1, IL-10 and TNFalpha during early postburn stage in burn patients.
- Author:
Xinjian KUANG
1
;
Kexian MA
;
Tiwu DUAN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Burns; immunology; Female; Humans; Intercellular Adhesion Molecule-1; blood; Interleukin-10; blood; Male; Middle Aged; Multiple Organ Failure; immunology; Sepsis; immunology; Shock; immunology; Time Factors; Tumor Necrosis Factor-alpha; analysis
- From: Chinese Journal of Burns 2002;18(5):302-304
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the postburn changes in the plasma levels of ICAM-1, IL-10 and TNFalpha during early postburn stage.
METHODSNineteen burn patients were enrolled in the study. The plasma levels of the above 3 kinds of factors were determined with ELISA in the peripheral plasma of the patients, plasma samples from 11 healthy volunteers were taken as the control.
RESULTSThe plasma levels of ICAM-1, IL-10 and TNFalpha increased obviously postburn, especially in those patients who were complicated with hypovolumic shock, sepsis and MODS (P < 0.05 - 0.01).
CONCLUSIONThe monitoring of the postburn changes in plasma levels of ICAM-1, IL-10 and TNFalpha might be helpful in the forecast of postburn sepsis and the development of MODS.
