The Value of Brachial-Ankle Pulse Wave Velocity as a Predictor of Coronary Artery Disease in High-Risk Patients.
10.4070/kcj.2010.40.5.224
- Author:
Won Woo SEO
1
;
Hyuk Jae CHANG
;
IkSung CHO
;
Yeon Yee YOON
;
Jung Won SUH
;
Kwang Il KIM
;
Yong Seok CHO
;
Tae Jin YOUN
;
In Ho CHAE
;
Dong Ju CHOI
;
Cheol Ho KIM
;
Eun Ju CHUN
;
Sang Il CHOI
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. ross1042@gmail.com
- Publication Type:Original Article
- Keywords:
Coronary artery disease;
Compliance
- MeSH:
Calcium;
Compliance;
Coronary Angiography;
Coronary Artery Disease;
Coronary Vessels;
Humans;
Pulse Wave Analysis;
Risk Factors;
ROC Curve;
Vascular Stiffness
- From:Korean Circulation Journal
2010;40(5):224-229
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Arterial stiffness has been known as an independent contributory factor for coronary artery disease (CAD). Brachial-ankle pulse wave velocity (baPWV) is widely used as a simple noninvasive measure of arterial stiffness. The aim of our study was to test whether baPWV had predictive value for CAD in the subset of patients with high pretest probability. SUBJECTS AND METHODS: We enrolled 174 consecutive patients who were referred for evaluation of suspected CAD, and who underwent both baPWV measurement and computed tomography (CT) for coronary artery calcium scoring (CACS) as part of a diagnostic work-up. Subsequently, 160 of those patients underwent invasive coronary angiography. The CAD indices consisted of 1) CACS, 2) modified Gensini scoring system, and 3) presence of obstructive CAD and 4) multi-vessel obstructive CAD. RESULTS: baPWV correlated with CACS (r=0.25, p=0.001), but not with modified Gensini scoring (r=0.10, p=0.19). However, after adjustment for factors influencing PWV, baPWV no longer correlated with CACS (r=0.14, p=0.14). By receiver operating characteristic (ROC) curve analysis, baPWV was neither a sensitive nor specific index for predicting the presence of obstructive CAD or multi-vessel obstructive CAD (sensitivity: 53% and 59%; specificity: 50% and 55%, respectively). CONCLUSION: Our findings demonstrated that baPWV is associated with CACS, however, this may be primarily attributed to common risk factors, such as age. Furthermore, baPWV may be of limited value in identifying patients at risk for CAD.
