An observation of repair of burn wound with consanguineous skin pretreated with Tripterygium wilfordii.
- Author:
Guifang YOU
1
;
Lühua LIANG
;
Langsheng ZHENG
;
Xinzhong LUO
;
Jincai LI
;
Junqi QIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Inflammatory Agents; pharmacology; Burns; surgery; Dexamethasone; pharmacology; Female; Graft Rejection; Graft Survival; Male; Plant Extracts; pharmacology; Rabbits; Skin; drug effects; Skin Transplantation; methods; Transplantation, Isogeneic; Tripterygium; Wound Healing
- From: Chinese Journal of Burns 2002;18(6):372-374
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore new source of skin for burn wound coverage.
METHODSSplit-thickness consanguineous skin was harvested from New Zealand white rabbit and was soaked in 200 g/L of multi-peptides of Tripterygium wilfordii, 50 g/L of dexamethasonel, on 9 g/L of normal saline solution for 15 - 30 mins, respectively. The consanguineous skin was thereafter grafted onto the whole layer skin defects in filial generation of rabbits with non-consanguineous skin as the control. The survival time and rejection of the grafted skin was observed.
RESULTSThe rejection appeared evidently less intense and survived significantly longer (43 +/- 3.5 days) when the consanguineous skin was pretreated by Tripterygium wilfordii. However the grafted consanguineous skin survived for 30 +/- 2.5 days when it was pretreated by dexamethasone. The grafted skin was quickly rejected and survived only for 11 +/- 1.6 days when the skin was pretreated by normal saline or the skin was non-consanguineous.
CONCLUSIONConsanguineous skin possessed partial compatibility with the recipient due to similar antigen, which was beneficial to the its survival, especially after the skin was pretreated.
