The influence of continuous renal replacement therapy on the plasma levels of endotoxin and cytokines in severely burned patients with sepsis.
- Author:
Hong-Bin LI
1
;
Yi-Zhi PENG
Author Information
- Publication Type:Journal Article
- MeSH: Burns; blood; complications; Endotoxins; blood; Humans; Interleukin-1beta; blood; Interleukin-6; blood; Interleukin-8; blood; Renal Replacement Therapy; Sepsis; blood; etiology; therapy; Tumor Necrosis Factor-alpha; blood
- From: Chinese Journal of Burns 2003;19(2):67-70
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the influence of continuous renal replacement therapy (CRRT) on the plasma levels of endotoxin and cytokines in severely burned patients with sepsis.
METHODSTen burn patients who received CRRT and another 10 without CRRT were investigated in terms of the changes in their plasma concentrations of endotoxin and some cytokines (TNFalpha, IL-1beta, IL-6, IL-8).
RESULTSThe plasma concentrations of endotoxin and all the cytokines (TNFalpha, IL-1beta, IL-6, IL-8) after CRRT treatment were significantly lower than those before the treatment (P < 0.01), and the plasma levels of the above factors at all the time points after CRRT treatment than those in patients were evidently lower by routine treatment (P < 0.05 - 0.01).
CONCLUSIONCRRT treatment could effectively lower the plasma levels of endotoxin and some cytokines (TNFalpha, IL-1beta, IL-6, IL-8).
