Urokinase-type plasminogen activator improves the reproductive function of male rats.
- Author:
Yu MING
1
;
Xue-jun SHANG
;
Cheng-liang XIONG
;
Xue-bing PANG
;
Fen XIONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Dose-Response Relationship, Drug; Infertility, Male; chemically induced; drug therapy; physiopathology; Male; Ornidazole; Random Allocation; Rats; Rats, Sprague-Dawley; Reproduction; drug effects; Sperm Motility; drug effects; Urokinase-Type Plasminogen Activator; pharmacology
- From: National Journal of Andrology 2006;12(11):963-967
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of urokinase-type plasminogen activator (uPA) on the reproductive function of the male rats with ornidazole-induced infertility.
METHODSFifty 10-12 weeks old adult male Sprague-Dawley rats were randomly divided into five groups: low-dosage uPA (330 IU/[kg x d]), mid-dosage uPA (1000 IU/[kg x d]), high-dosage uPA (3000 IU/[kg x d]), ornidazole (400 mg/[kg x d]) and control (0.5% Carboxymethylcellulose solution). The ornidazole group was treated by gastric gavage, and the rats in the uPA groups given both ornidazole by gastric gavage and uPA by intraperitoneal injection at the same time. All the rats were treated for 20 days consecutively, followed by copulation experiment. The rats were sacrificed and the reproductive system explored.
RESULTSThe percentage of motile sperm and the number of embryos in the high-dosage uPA group increased significantly (P < 0.01) compared with the ornidazole group.
CONCLUSIONuPA can antagonize ornidazole-induced infertility in male rats. The effect might be attributed to the improvement of sperm motile function by uPA.
